UniPat AI has introduced a benchmark called Science Prediction Universe, or SPU. This tool is designed to test the ability of artificial intelligence agents to predict the outcomes of real laboratory research before actual data is obtained.
According to the company's data, among the thirteen tested agent configurations, the average score was below 0.5 on a scale where perfect prediction is rated as 1 point and random guessing as 0.
SPU includes 116 tasks covering 4207 experiments conducted in the fields of chemistry, materials science, biology, and medicine. One hundred publicly available tasks were created based on 85 scientific papers published in 11 Nature portfolio journals between January 2025 and August 2026. An additional 16 closed tasks are based on unpublished experiments conducted in collaboration with partner laboratories concerning VHH nanobodies, reaction conditions, electrolytes, and Magrolimab antibody variants; these private tasks are not published.
Each task records the candidates, materials used, testing conditions, and measurement method of a real experiment. The agent is provided with eight hours of work time in a container equipped with 8 central processors, 16 GB of RAM, and one NVIDIA H20 GPU. It has the capability to search the internet and install scientific software, after which it must rank the candidates according to the measured result. A separate offline container evaluates this ranking using Spearman correlation, and the output of the tools is checked for source article identifiers to restrict answer searching.
The first round of testing included 12 advanced models in 13 different configurations. UniPat AI reports that the Claude Opus 5.5 model demonstrated the highest average score—0.486, but most of its runs failed due to safety concerns, so it was evaluated on fewer tasks. Overall, only 34% to 52% of tasks managed to exceed the set probability threshold. The company grouped six configurations into a leading tier, which shows results approximately 0.15 higher than the others when performing the same tasks.
The analysis indicates that the bottleneck is judgment, not tool usage. During the study, agents showed a higher degree of agreement among themselves (0.52) than with real experimental data (0.33). Other findings noted that consultants for the project were drawn from institutions such as Stanford, Cornell, Harvard, Peking University, HKUST, and FutureHouse, alongside laboratory partners. One hundred public tasks are available on Hugging Face as Harbor tasks under the CC BY 4.0 license, and the corresponding code is hosted on GitHub under the Apache 2.0 license.


