Study: Cannabis Use Increases Risk of Atherosclerosis Development
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Study: Cannabis Use Increases Risk of Atherosclerosis Development

American researchers have established a link between cannabis use and an increased probability of developing cardiovascular atherosclerotic diseases.

It is important to note that this elevated risk was observed even in young individuals who did not have other known risk factors, such as tobacco smoking. The analysis covered data from 577,057 people collected between 2020 and 2024 from various states in America.

The results of this scientific investigation were presented at the American College of Cardiology Scientific Session.

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Gum disease can lead to kidney problems, doctor explains oral hygiene maintenance methods
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Gum disease can lead to kidney problems, doctor explains oral hygiene maintenance methods

Maintaining oral health is critically important for preventing kidney diseases, despite the apparent illogical nature of this statement. Medical science establishes a link between the condition of the mouth, especially gum health, and kidney health. According to data from the National Kidney Foundation, gum disease can increase the risk of various kidney problems, which has been confirmed in several of the Foundation's studies.

Studies show that these systems are connected through the body's immune and circulatory systems. A correlation has been found between gum disease (periodontitis) and kidney diseases. The body's fight against bacteria causing gum problems leads to inflammation. Although inflammation is a natural reaction, its prolonged persistence can negatively affect the kidneys. Furthermore, dental infections can complicate blood pressure control and increase risks during surgery or transplantation, especially in people who already suffer from kidney diseases, are on dialysis, or are taking immunosuppressant drugs after transplantation.

It is important to understand that gum disease is not a direct cause of kidney failure, and it cannot be prevented solely by brushing teeth and using dental floss. Nevertheless, caring for oral hygiene is an integral part of overall bodily care.

Dr. Ghotechkar emphasizes the need to pay attention to oral hygiene to maintain good dental health. He recommends brushing teeth at least twice daily and avoiding sweets in the evening. If toothache or mouth ulcers appear, one should consult a doctor. It is also advised to refrain from consuming tobacco products (pan masala, gutkha) and alcohol.

The kidneys also follow the body's sleep cycle. Therefore, adequate sleep contributes to improving kidney health. It is recommended to sleep seven to eight hours every night. Sleep helps regulate blood pressure and blood glucose levels, which are two extremely important factors for kidney health. Studies have also shown that lack of or excess sleep can increase the risk of developing kidney diseases or proteinuria. However, these studies only demonstrate a correlation, not that chronic kidney disease arises exclusively due to lack of sleep.

Study shows that Rituximab use in multiple sclerosis increases the risk of inflammatory bowel disease
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Study shows that Rituximab use in multiple sclerosis increases the risk of inflammatory bowel disease

Swedish researchers have completed a population cohort study and concluded that the use of the drug Rituximab, which is a monoclonal antibody to the B-cell antigen CD20, for treating multiple sclerosis is associated with an increased risk of developing inflammatory bowel disease.

The results of this study were officially published in the scientific journal JAMA Neurology.

Research indicates that apple consumption can aid cardiometabolic and intestinal health
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Research indicates that apple consumption can aid cardiometabolic and intestinal health

A comprehensive review analyzing 38 studies revealed evidence that consuming apples can be beneficial for cardiometabolic health. The observed effects include improvements in glycemic control, blood vessel function, and gut microbiota composition.

This study, published in the scientific journal Food & Function, compiled various clinical research and highlighted potential advantages related to the nutrients, fibers, and bioactive compounds present in the fruit. Researchers from Italy described the antioxidant and anti-inflammatory effects of apples, which positively impact the endothelium, the inner cellular layer of arteries, thereby promoting vascular function.

The analysis also pointed to changes in the constitution of the gut microbiota, reinforcing the role of apples in supporting cardiometabolic health. However, the authors warn that the food alone does not guarantee miraculous results, requiring a critical view of the findings.

Caution in interpreting the results

Isis Helena Avelino, a nutritionist at Einstein Israelite Hospital, emphasized that there is variation among the 38 analyzed studies, both in the populations involved and in the quantities consumed, which demands prudence before drawing definitive conclusions.

Apples possess a combination of nutrients and bioactive compounds already recognized by science for their cardiovascular benefits. Minerals present in the fruit include potassium and magnesium, as well as vitamins, notably those in the B complex and vitamin C.

Fibers, with special mention of pectin—a soluble type—play an important role. By forming a gel in the digestive tract, pectin slows gastric emptying and carbohydrate absorption, aiding in glycemic control and reducing the risk of diabetes. Furthermore, it has prebiotic function, nourishing the microbiota, since part of the fiber is not digested and reaches the large intestine, serving as food for beneficial microorganisms.

The review also emphasizes that regular apple consumption is correlated with an increase in certain bacteria, such as bifidobacteria. During the fermentation process, short-chain fatty acids (SCFAs) are generated, which are linked to maintaining intestinal barrier integrity, controlling inflammation, and modulating energy metabolism, as detailed by the Einstein nutritionist.

Polyphenols and apple varieties

Another highlight is the high concentration of polyphenols, substances known for their antioxidant and anti-inflammatory properties. Renata Carnauba, a researcher at the Faculty of Pharmaceutical Sciences of the University of São Paulo (USP), specified that the main polyphenols found are flavonoids, with quercetin, catechins, and proanthocyanidins being the most prominent in this class.

Red apples contain anthocyanins, which belong to the same family of pigments. Although polyphenols are distributed throughout the apple (pulp, peel, and seed), the highest concentration is found in the peel, which holds over 80% of all flavonoids. Therefore, the recommendation is to consume the fruit without peeling it, provided it has been properly sanitized.

The researcher also advises diversifying the varieties consumed daily, as the profile of bioactive compounds varies among apple types. To prolong the polyphenol content, she suggests keeping the fruits refrigerated.

The apple, originating from Central Asia, is widely consumed globally. In Brazil, its cultivation is mainly concentrated in the South region due to its preference for temperate climates. Some popular varieties include Fuji, known for its aromatic, firm, and crisp pulp with a reddish skin; Gala, which presents a balance between acids and sugars in its juicy pulp; and Granny Smith, a green apple type common in the Brazilian market, characterized by its white and acidic pulp.

Red varieties, nicknamed Argentine apple, are also mentioned, which have a red and shiny skin and can become mealy when overly ripe.

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