A monograph dedicated to the population genomics of Uzbeks has been published in Uzbekistan. Specialists collected and analyzed numerous scientific works to emphasize that implementing personalized medicine requires considering specific national genetic characteristics.
The majority of global genetic projects are based on data from European populations, as over ninety percent of studies in the international GWAS catalog are dedicated to them, while the share of Asian groups is only 3.14%. This circumstance means that conclusions drawn from such studies cannot be automatically applied to other peoples, including Uzbeks.
The authors of the monograph thoroughly studied 301 scientific publications, 34 of which were examined most carefully. The book presents data on hereditary factors associated with various diseases, such as cardiovascular, oncological, and metabolic ones. Special attention was paid to type 2 diabetes, where researchers found that the actual number of cases in the country exceeds the official statistics of dispensaries by ten times.
Scientists were able to identify genetic risk markers, develop a screening panel, and test it. The results obtained can serve as a foundation for creating diagnostic systems that allow doctors to prescribe therapy taking into account the unique features of each patient.
The preparation of this monograph was carried out by the Center for Advanced Technologies in cooperation with the Republican Cardiology Center and Tashkent State Medical University. This work is significant not only for national science but also opens prospects for transitioning from a universal medical approach to a more individualized system of prevention, diagnosis, and treatment.
It is worth noting that previously, in October 2025, scientists at the Center for Advanced Technologies completely sequenced and analyzed the genes of Uzbeks for the first time in the country's history. Almost a third of the discovered mutations were unknown to world science and were added to international databases.


