João César Machiori, Brazilian with Down syndrome, reaches 80 years old and is the oldest in the country
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Noticias ao Minuto
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João César Machiori, Brazilian with Down syndrome, reaches 80 years old and is the oldest in the country

João César Machiori, known by family and friends as Neno, has reached the age of 80, becoming the oldest person with Down syndrome registered in Brazil. He resides in São Manuel, in the inland region of São Paulo, and is described by his relatives as someone who radiates joy.

One of Neno's sisters, who shares his residence, stated that he is the center of the home, placing his well-being above everyone else's. Neno is the youngest of three siblings and never had access to formal education, knowing neither how to read nor write. Despite this, he maintains an organized office where he keeps collections, magazines, and antiques.

The family emphasizes that, in contrast to the time he was born, when the average life expectancy for people with Down syndrome was only about 12 years, today there are more stimuli, allowing individuals with the condition to participate in activities such as making films, attending colleges, dating, and marrying.

The milestone of 80 years is notable because it exceeds the Brazilian average life expectancy, which, according to the Brazilian Institute of Geography and Statistics (IBGE), is approximately 76 years. Dr. Orestes Vicente Forlenza, head of the Psychiatry Department at the University of São Paulo, classified 80 years as rare for someone with Down syndrome, comparing it to reaching 100 years or more, and attributed the increase in longevity to the control and correction of congenital diseases.

However, the family believes that Neno's active lifestyle also contributed to his long life. He enjoys walking and dancing, maintaining a routine that includes napping after lunch, walking to the bakery, visiting the church, and going to the gym weekly.

Although considered very friendly, Neno's communication has become more challenging after suffering a Stroke (CVA). A relative commented that, even with verbal difficulties, she can understand his state and desires through his gaze.

In summary, everyone who lives with Neno agrees that his most striking characteristic is the contagious joy he transmits.

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Western Cape Chronic Medication Dispensing Centre Improves Drug Accessibility and Reduces Healthcare Facility Burden

The Chronic Dispensing Unit (CDU) of the Western Cape Department of Health and Wellness helps patients quickly receive pre-packed medication closer to their homes, thereby reducing crowding in medical facilities.

Currently, the CDU processes approximately two million individual units of medication, converting them into 400,000 individual patient packs monthly. Through this system, medication valued at an average of 42 million rand is distributed across the province each month, both to healthcare facilities and approved alternative dispensing points.

By enabling stable patients to collect ready-made medicines near home, the CDU alleviates facility overcrowding. This allows healthcare workers to dedicate more time to consultation, managing acute cases, and providing clinical care.

After verifying prescriptions, the CDU packages individualized medications and sends them to healthcare facilities and alternative collection points such as community centers, health centers, and mailboxes. Providing scheduled collection dates allows patients to efficiently pick up their medication, avoiding long queues or clinic visits.

Role of Stock and Program Growth

Following a visit to the facility, Premier Alan Windey emphasized that the six- or eight-week supply maintained by the CDU helps mitigate supply disruptions, supports adherence to treatment regimens, and improves access to healthcare. Windey noted that the scale of this operation is impressive, and the CDU plays a vital role in buffering medication stocks.

He added that maintaining a sufficient six-to-eight-week stock helps prevent the consequences of supply interruptions, promotes treatment adherence, and protects residents' health.

The program has shown significant growth since its launch in 2005, when fewer than a thousand packs were dispensed monthly; in the 2025/26 financial year, the CDU registered 3.26 million applications.

Benefits for Patients and Staff

The Minister of Health and Wellness for the Western Cape, Mireille Wenger, noted that the CDU benefits both patients and staff by making medication collection convenient—allowing quick pickup near home or work—and reducing waiting times in clinics.

She explained that this also improves the quality of patient care. When stable patients taking chronic medications do not have to wait inside a medical facility just to collect medicine, clinics become less congested, and healthcare workers gain more time for consultation, managing acute conditions, and supporting those needing clinical care.

Wenger also reported that about 6% of the packs delivered to facilities remain unclaimed. Patients are sent SMS reminders before collection dates, and they are advised to keep their contact details updated.

Highlighting the social significance of the program, Wenger stated: 'By bringing chronic medication closer to patients and freeing up staff, the CDU helps build a caring and dignified healthcare system.' Patients with a stable clinical profile who take chronic medications are advised to consult with local clinic or facility staff to determine their eligibility for the CDU program.

Stellenbosch University study shows how social media can exacerbate depression
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Stellenbosch University study shows how social media can exacerbate depression

A researcher from Stellenbosch University discovered that negative emotions can be reinforced through social media interactions, with individuals suffering from depression being particularly susceptible to this influence.

For people with depression, the internet can offer an opportunity difficult to find in real life: a space for open communication, finding like-minded people, and feeling less alone. However, these online connections can also have a dark side, as negative emotions can potentially reinforce each other when communicating on social media.

This is the problem studied by Dr. Kurt Marais, a lecturer in the Department of Logistics at Stellenbosch University (SU), as part of his recently completed doctoral dissertation in operations research. He investigated how emotional states transfer in online communities, focusing specifically on depression, and examined how this process can be measured and better understood.

The study focused on a subreddit dedicated to depression on the Reddit platform, where users from different countries, age groups, and social strata share their experiences, seek advice, and support others. Over 56 days, Marais analyzed 12,133 unique posts. The average post length was 178 words, although the longest contained 5,192 words. Most posts came from users in the United States, the United Kingdom, Canada, India, and Germany.

Among the most frequently occurring words were 'like', 'feel', 'life', and 'want', reflecting users' attempts to describe their emotional experiences and desire to feel more than depressed. There was a frequent use of first-person stop words such as 'I', 'am', 'my', and 'me'. Words like 'feeling', 'depression', and 'thinking' appeared in the list of most frequently used words alongside 'feel', 'depressed', and 'think', respectively.

The study also revealed patterns in when people most often posted content. Activity increased at the beginning of the week, with Mondays and Tuesdays recording more posts than other days, while Saturdays were relatively quieter. The day of the week also influenced user reactions: Monday posts attracted more upvotes, while Saturday posts received more comments.

Marais also found that the online community became particularly active late at night. 'It is interesting that the number of posts increased from 10 PM to 5 AM. This confirms previous research suggesting that people with depression tend to be more active on social media at night.'

However, one of the most significant findings was the influence of users' emotions on each other. Marais calls this emotional reinforcement—a process where people can amplify feelings expressed by others in their online network. He explained that if two people post negative content, they are likely to continue doing so more often and longer, thereby intensifying these emotions. This effect was even stronger among people with depression. Although it is also observed with positive emotions, the effect is not as strong in the case of exchanging negative emotions.

To better identify these emotional patterns, Marais developed a depression-specific lexicon, which is a specialized list of words and expressions related to depressive emotional vocabulary. He found that this tool performed better than general sentiment analysis tools and could identify relevant language in posts about other mental disorders, including anxiety and PTSD.

Marais also compared his approach with large language models trained on mental health-related material, asserting that his specialized lexicon offers a more reliable way to determine depressive mood in this context. The study was not limited to Reddit. Using insights gained from the online community, Marais created an agent-based simulation model to study how mental health-related content might spread on Twitter, now known as X. The model was based on observed user behavior, realistic interaction models, natural language processing, and potential intervention strategies. The tweets used in the study were collected before Twitter rebranded to X, so the results pertain to the platform's design, features, and algorithms at that time.

Some posts contained simple statements about personal experiences with depression, including phrases such as 'I am diagnosed with depression', 'I am fighting depression', and 'I suffer from depression'.

The simulation showed that people's emotional states can persist over time, and interaction with others can also influence these states. Marais found that repeated exposure to similar negative emotions can strengthen and deepen these feelings.

For Marais, these findings have implications beyond academic research. He noted that researchers gain tools to study mental health online, practitioners gain insight into contemporary experiences of depression, platform developers receive evidence-based recommendations for improving user well-being, and social media users themselves better understand their role in algorithm-driven environments. This study highlights the complex role that social media can play in the lives of people suffering from depression. Online platforms can provide connection and support, but the same networks can create conditions where negative emotional patterns are constantly reinforced. Marais believes that his work can contribute to a better understanding of this relationship and help shape a healthier digital environment.

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