New weekly HIV treatment is attracting attention due to clinical trial results, offering some people living with HIV the possibility of taking medication weekly instead of daily. These developments occur amid growing researcher interest in long-acting HIV treatments that can reduce medication frequency while maintaining viral suppression.
Daily Treatment Remains the Standard
Taking antiretroviral drugs daily remains a key element of HIV therapy in South Africa. National guidelines from the Department of Health recommend antiretroviral therapy for people living with HIV to achieve and maintain viral suppression. These recommendations include treatment based on dolutegravir, which is taken once a day along with other antiretroviral drugs in established regimens.
Daily intake is already established and part of South Africa's national HIV control program. However, for many patients, remembering the daily dose can be challenging. Missed doses, travel, the need for confidentiality, and managing medication within daily routines can affect adherence.
What is the Weekly Pill?
The new drug is a combination of two medications—itrastvir and lenacapavir—in an investigational oral form designed for once-weekly administration. Phase 3 trial results from ISLEND-1 showed that weekly treatment maintained viral suppression in adults living with HIV who already had viral suppression and transitioned from existing daily treatment. After 48 weeks, the weekly treatment was found to be no worse than Biktarvy, a daily HIV medication.
A second Phase 3 study, ISLEND-2, also investigated this weekly combination in individuals who had already achieved viral suppression and switched from standard daily HIV treatment. However, it should be noted that these results do not mean the weekly pill is yet available to patients. The treatment remains experimental, and developers are expected to submit clinical trial data to regulatory bodies for review.
What is the biggest difference?
The most obvious and significant difference lies in the frequency of administration. Patients on standard daily oral HIV treatment must take medication every day. The investigational treatment reduces this frequency to one dose per week. This could simplify treatment for some individuals who struggle with a daily dosing schedule.
Nevertheless, reducing the frequency of medication does not mean adherence becomes less important. Weekly treatment must still be taken according to the prescribed schedule. Furthermore, the approaches differ in availability: daily HIV treatment is already integrated into the South African healthcare system, whereas the weekly combination is not yet approved for routine use.
What about long-acting injections for HIV?
The weekly pill is part of a broader trend toward HIV medications that do not require daily intake. According to U.S. National Institutes of Health data, long-acting HIV drugs can be administered at intervals ranging from two weeks to six months, depending on the specific drug.
The World Health Organization has also recommended long-acting injectable cabotegravir and rilpivirine as an alternative switching option for eligible individuals who have achieved full viral suppression on oral therapy. South Africa is also implementing long-acting injectable lenacapavir for HIV prevention. It is important not to confuse prevention and treatment: using a drug to prevent HIV does not guarantee that the same product is available or approved for treating people already infected with HIV.
Can weekly treatment improve adherence?
This could potentially simplify treatment for some patients. The World Health Organization has highlighted adherence challenges associated with daily oral treatment and believes that long-acting HIV drugs can offer benefits such as reduced dosing frequency, convenience, and privacy.
At the same time, WHO has pointed out issues such as cost, accessibility, drug resistance, and implementation within the healthcare system as critical aspects when introducing long-acting HIV drugs. Thus, the weekly pill could serve as an intermediate solution between daily pills and long-acting injection methods: medication would still be taken at home, but much less frequently.
Does this mean replacing daily ARVs?
No. The new data does not imply that people living with HIV should stop taking their current medications or change their treatment. Existing HIV treatment guidelines in South Africa remain in effect, and the weekly combination is still in the research phase. New studies point to a future where people with HIV may have more treatment options, depending on regulatory approval, clinical suitability, and availability.
For now, people living with HIV should continue taking medication as prescribed by their doctor and consult with their healthcare provider before making any changes to their treatment.