A mother residing in London, United Kingdom, participated in an experimental surgical procedure in the United States that made it possible to correct a congenital anomaly in her son before birth.
Maisie Savage, 29, was operated on when she was 26 weeks pregnant. The baby, Theo, had complex gastroschisis, a malformation characterized by the complete failure of the abdominal wall to close during gestation, resulting in the development of the intestine outside the abdominal cavity.
Theo became the first British baby to undergo intrauterine surgery to treat this condition, integrating the first global clinical study focused on prenatal treatment of complex gastroschisis. He was the third baby to participate in this global study. Currently five months old, Theo was born in February via normal delivery in Texas, USA.
What is gastroschisis and why was Theo's case serious
Gastroschisis affects approximately one in every three thousand newborns in the UK annually. Even in the most favorable scenarios, these babies often require weeks in neonatal intensive care unit (NICU), tube or intravenous feeding, and corrective surgical interventions.
In cases considered complex, like Theo's, NICU stays can extend up to six months. Furthermore, the baby may require multiple surgeries, intravenous feeding for up to two years, and, in some situations, an intestinal transplant. Despite receiving high-quality medical care, one in ten of these babies dies.
Theo's parents, Josh French, 36, also a teacher, were unaware of the condition during pregnancy. The father told BBC News that during the 20-week scan, they were just anxious to see an image of the baby, without knowing it would be a boy. French described the diagnosis as a shock and an 'extremely frightening' experience.
The journey to experimental surgery
When Theo was 24 weeks pregnant, specialists at Great Ormond Street Hospital in London began preparing the family for the baby's first six months of life. Upon identifying the most severe form of the disease, doctors referred him to the Texas Children's Hospital, located in Houston.
In Texas, a team of pediatric and fetal surgeons, led by Dr. Michael Belfort, conducted the clinical study. Belfort already had pioneering experience in similar uterine surgeries performed to treat babies with spina bifida.
Maisie Savage was notified about the need to travel immediately to Texas and stay there until the end of the pregnancy, which she described as 'a huge decision'. As part of the study protocol, she first visited the hospital in Leuven, Belgium, where specialists administered a Botox injection through the uterus into Theo's abdominal wall, aiming to relax the muscles and facilitate the surgical procedure.
How the procedure was performed
The surgery took place the previous year, in November. Doctors proceeded to partially expose the uterus to position the baby, drained the amniotic fluid, and filled the uterine cavity with carbon dioxide (CO2) to increase available space. Subsequently, using a minimally invasive technique, Theo's organs were relocated to the abdomen, which was then closed with sutures.
Savage had a scar twice as large as a C-section and still had 14 weeks of pregnancy ahead. Theo frequently kicked and hit the scar, causing pain. She commented that 'the recovery was difficult. But it was worth it.'
French described the waiting period during the procedure as agonizing, stating that 'that day felt like it lasted a week. It was very difficult to wait without knowing exactly what was happening at each stage of the procedure.'
Results and next steps in the study
Dr. Belfort, who is responsible for obstetrics and gynecology at Texas Children's Hospital, evaluated the outcomes, stating: 'The mother, the baby, the surgery, the time it was performed, the fact that we had no complications during or after the fetal surgery... All of this is extraordinary.'
If the clinical study is successful, Paolo de Coppi, a professor of pediatric surgery at Great Ormond Street Hospital and director of the stem cell and regenerative medicine research center at University College London, will take over the procedure in the UK. De Coppi expressed hope that this treatment could soon be offered to a larger number of patients.
Belfort expressed enthusiasm for the collaboration between the two institutions and pointed to broader implications in the medical field. He emphasized that 'the inside of the uterus has become a new field for surgical innovation,' citing spina bifida and gastroschisis as mere examples. He believes that in the future, cardiac surgeries and certain fetal pulmonary procedures can be performed during pregnancy.
Back in London, Savage confirmed that Theo is well, saying that 'everything they did completely changed the course of history, which could have started very difficultly. Today he is great. He is essentially a baby like any other.'
French concluded by expressing gratitude: 'We feel extremely privileged. While we were there, we received exceptional care. They alleviated one of the most traumatic moments of our lives. And today we have this little boy. We couldn't be happier.'



